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Cialis Stopped Working? What To Do Next

Erectile dysfunction affects about 5-20% of men in the world. Age is one of the risk factors for developing the condition. However, it can also affect young men.

Cialis (brand name for tadalafil) is one of the major ED medications. Even though it works for most people, sometimes it may not work or stop working altogether.

How Cialis Works

Cialis works by blocking PDE5. 

Phosphodiesterase 5 (PDE5) is an enzyme present on the walls of blood vessels that affects blood flow. Cialis (and the other medications) are referred to as PDE5 inhibitors. 

They block the enzyme thus, preventing it from working. As a result, blood flows to the penis, making it erect. 

Vardenafil (Levitra), sildenafil (Viagra), and avanafil (Stendra) are other common PDE5 inhibitors for treating erectile dysfunction.


Cialis starts working 30 min to 1 hour after taking and can last for up to 36 hours. Unlike other drugs, you need to be sexually aroused for it to work.

Possible Reasons Why It’s Not Working

You’re Using Cialis Incorrectly

Cialis may not work if you take it a few minutes before sex. It can take up to an hour before it works. So, ensure you take your dose at least an hour before engaging in sex.

Wrong Dosage

You should take the dosage prescribed by your doctor. If it’s not working or is less effective, talk to your healthcare provider to see if a higher dosage will be appropriate.

ED Caused by Psychological Conditions

If your ED is caused by mental health issues such as anxiety and depression, Cialis might not work. It treats physical issues affecting blood flow and not psychological causes.

Physical Conditions are Causing ED

Diabetes, obesity, and high blood pressure can cause ED. Sometimes, ED caused by some physical conditions might not improve with Cialis. 

What To Do If Cialis Stopped Working

It can be frustrating if a treatment like Cialis doesn’t work for you. However, you can opt for other options such as:

  • Change your lifestyle: Exercise, reduce stress, eat healthy diets, and avoid alcohol.
  • Testosterone therapy: For ED caused by low testosterone levels.
  • Penile implants: Devices placed surgically in the penis to allow you to get and maintain an erection.
  • Vacuum constriction device
  • Penile vascular reconstructive surgery for ED caused by penis trauma in young males.
  • Intraurethral therapy: You place medication through the opening on the penis into the urethra.
  • Other PDE5 inhibitor medications: Viagra, Levitra, and Stendra.
Take Charge. Rise Again!

All is not lost if Cialis is not working. You can explore other treatment options. Need to talk to a professional physician? Connect with one at Phoenix, an online men’s clinic in Canada.


Talk to a licenced physician, no waiting time, no visiting the pharmacy, and your medication is delivered discreetly and free of charge. Talk to us to take control of your erections and rise again.

Rise Again

Take the first step and connect with a Phoenix physician today.
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